Benavides, Mi Jung Chang, Yaozu Ye, Nirag Jhala, Michael P Murphy, Balaraman Kalyanaraman and Victor-Darley Usmar. Balu K Chacko, Anup Srivastava, Michelle Johnson, Gloria A.Patel Endothelial surface N-glycans mediate monocyte adhesion and are targets for anti-inflammatory effects of PPAR ligands. Darley-Usmar Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes. Johnson, Balu K.Chacko, Aparna Venkatraman, Aimee Landar, Angela M. Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagy. Johnson, Aimee Landar, Jianhua Zhang and Victor M.
Benavides, Balu Chacko, Xiaosen Ouyang, Michelle S. Role for endothelial N-glycan mannose residues in monocyte recruitment during atherogenesis Arterioscler Thromb Vasc Biol.
David W Scott, Jie Chen, Balu K Chacko, James G Traylor Jr., Anthony W Orr and Rakesh P Patel.Utilization of fluorescent probes for the quantification and identification of subcellular proteomes and biological processes regulated by lipid peroxidation products. Cummins TD, Higdon AN, Kramer PA, Chacko BK, Riggs DW, Salabei JK, Dell'italia LJ, Zhang J, Darley-Usmar VM, Hill BG.Controlling Radicals in the Powerhouse: Development of MitoSOD. Mitchell T, Chacko BK, Darley-Usmar V.Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo. Vitturi DA, Sun CW, Harper VM, Thrash-Williams B, Cantu-Medellin N, Chacko BK, Peng N, Dai Y, Michael Wyss J, Townes T, Patel RP.These developments can be extended using the bioenergetic function in blood leukocytes to determine the individual susceptibility to disease development. Recent literature demonstrates a strong correlation between alteration in mitochondrial bioenergetics in leukocytes and the development of cardiovascular and metabolic diseases. An important aspect of the development of diseases is the individual susceptibility which is determined by genetic and lifestyle factors and interestingly enough, these factors have shown to significantly influence the bioenergetic capability of the individual. Chacko's research interests are focused on the alterations in mitochondrial regulation of cellular function in the pathogenesis of acute and chronic inflammatory diseases. He is currently an Instructor in the Department of Pathology. He completed postdoctoral training in Vascular Biology with Dr.Rakesh P Patel and in the area of Mitochondrial Biology with Dr.Victor Darley-Usmar at the University of Alabama at Birmingham. from Sree Chitra Tirunal Institute of Medical Sciences and Technology, India. Chacko received his MSc in Medical Biochemistry degree from Kasturba Medical College, Mangalore, India and his Ph.D. You need JavaScript enabled to view it.ĭr. Research Associate, Pathology, Molecular & Cellular Pathology This email address is being protected from spambots.